Although low bone mineral density (BMD) is strongly associated with increased fracture risk, up to 50% of those who suffer fractures are not detected as high-risk patients by BMD testing. Thus, new approaches may improve identification of those at increased risk for fracture by in vivo assessment of altered bone tissue properties, which may contribute to skeletal fragility.
https://www.ncbi.nlm.nih.gov/pubmed/25862290
Bone. 2018 Jan;106:90-95. doi: 10.1016/j.bone.2015.03.021. Epub 2015 Apr 7.