Day: February 8, 2022

F Malgo 1, N A T Hamdy 1, T J Rabelink 2, H M Kroon 3, K M J A Claessen 4, A M Pereira 4, N R Biermasz 4, N M Appelman-Dijkstra 1 Eur J Endocrinol. 2017 Mar;176(3):339-347. doi: 10.1530/EJE-16-0808. Epub 2017 Jan 11. PMID: 28077497 DOI: 10.1530/EJE-16-0808 Objective: Acromegaly is a rare disease caused by excess growth hormone (GH) production by the pituitary adenoma. The skeletal complications of GH and IGF-1 excess include …

Bone material strength index as measured by impact microindentation is altered in patients with acromegaly Read More »

Kara L Holloway-Kew 1, Pamela Rufus-Membere 2, Kara B Anderson 2, Amelia Betson 2, James Gaston 2, Mark A Kotowicz 3, Adolfo Diez-Perez 4, Natalie K Hyde 2, Julie A Pasco 5 Bone. 2020 Apr;133:115241. doi: 10.1016/j.bone.2020.115241. Epub 2020 Jan 16. PMID: 31954850 DOI: 10.1016/j.bone.2020.115241 Background: Patients with chronic kidney disease (CKD) are at high risk for fracture. The ability of bone mineral density (BMD) to predict fractures in CKD patients has been inconsistent. Other measures such …

Bone material strength index is associated with prior fracture in men with and without moderate chronic kidney disease Read More »

Guillermina Orduna 1, Leonardo Mellibovsky 1, Eugenia Abella 2, Xavier Nogués 3, Roser Granero 4, Natalia García-Giralt 1, Marta Pineda-Moncusí 1, Roberto Güerri-Fernández 1, Daniel Prieto-Alhambra 5, Adolfo Díez-Pérez 1 J Bone Miner Metab. 2020 Jul;38(4):563-569. doi: 10.1007/s00774-020-01084-3. Epub 2020 Jan 23. PMID: 31974675 DOI: 10.1007/s00774-020-01084-3 Introduction: Monoclonal gammopathy of uncertain significance (MGUS) is highly prevalent in older adults and affects bone structure, with osteoporosis and increased risk of fractures in up to 14% of affected patients. Dual-energy X-ray …

Bone tissue quality in patients with monoclonal gammopathy of uncertain significance Read More »

S Ballesta 1 2, R C Güerri-Fernández 2 3 4, J J Chillarón 5 6 7, A Güell 2 8, S Herrera 2 3, E Torres 3, N G Ascoeta 1, J A Flores Le-Roux 1 2 4, A Díez 2 3 4 Osteoporos Int. 2020 Jan;31(1):175-180. doi: 10.1007/s00198-019-05178-1. Epub 2019 Oct 23. PMID: 31641800 DOI: 10.1007/s00198-019-05178-1 Diabetes mellitus is associated with a higher risk of fracture. In this study, we analysed the bone quality of premenopausal women with type 1 diabetes mellitus by microindentation. No differences in …

The use of microindentation for the study of bone properties in type 1 diabetes mellitus patients Read More »

M J Pérez-Sáez 1 2 3, S Herrera 2 4 5, D Prieto-Alhambra 2 5 6, L Vilaplana 2 4 5, X Nogués 2 4 5, M Vera 1 2, D Redondo-Pachón 1 2 3, M Mir 1 2, R Güerri 2 4 5, M Crespo 1 2 3, A Díez-Pérez 7 8 9, J Pascual 10 11 12 Osteoporos Int. 2017 Sep;28(9):2723-2727. doi: 10.1007/s00198-017-4065-5. Epub 2017 May 11. PMID: 28497224 DOI: 10.1007/s00198-017-4065-5 Bone health is assessed by bone mineral density (BMD). Other techniques such as trabecular bone score and microindentation could improve the risk of fracture’s estimation. Our chronic kidney disease (CKD) patients presented …

Bone density, microarchitecture, and material strength in chronic kidney disease patients at the time of kidney transplantation Read More »

S Herrera 1, R Soriano 1, X Nogués 1, R Güerri-Fernandez 1, D Grinberg 2, N García-Giralt 1, N Martínez-Gil 2, S Castejón 1, A González-Lizarán 1, S Balcells 2, A Diez-Perez 3 4 Osteoporos Int. 2017 Dec;28(12):3489-3493. doi: 10.1007/s00198-017-4198-6. Epub 2017 Aug 25. PMID: 28842728 DOI: 10.1007/s00198-017-4198-6 Camurati-Engelmann (CE) is a very rare disease affecting one in every million persons worldwide. It is characterized by an enlargement of long bones. We aimed to assess bone characteristics in three siblings with different …

Discrepancy between bone density and bone material strength index in three siblings with Camurati-Engelmann disease Read More »

Sabina Herrera 1, Jordi Pérez-López 2, Marc Moltó-Abad 2, Roberto Güerri-Fernández 1, Elena Cabezudo 3, Silvana Novelli 4, Jordi Esteve 5, Albert Hernández 6, Inmaculada Roig 7, Xavier Solanich 8, Daniel Prieto-Alhambra 9 10, Xavier Nogués 1, Adolfo Díez-Pérez 1 J Bone Miner Res. 2017 Jul;32(7):1575-1581. doi: 10.1002/jbmr.3121. Epub 2017 May 11. PMID: 28263001 DOI: 10.1002/jbmr.3121 Gaucher disease (GD), one of the most common lysosomal disorders (a global population incidence of 1:50,000), is characterized by beta-glucocerebrosidase deficiency. Some studies have demonstrated bone infiltration in up to …

Assessment of Bone Health in Patients With Type 1 Gaucher Disease Using Impact Microindentation Read More »

J R Starr 1, G Tabacco 1 2, R Majeed 1, B Omeragic 1, L Bandeira 1 3, M R Rubin 4 Osteoporos Int. 2020 Feb;31(2):327-333. doi: 10.1007/s00198-019-05177-2. Epub 2019 Nov 13. PMID: 31720712 DOI: 10.1007/s00198-019-05177-2 PTH levels might be associated with bone material strength as measured by impact microindentation. Resistance to microfracture is decreased in hypoparathyroidism and appears to be associated with more severe disease and to improve with PTH replacement. Introduction: …

PTH and bone material strength in hypoparathyroidism as measured by impact microindentation Read More »

Manuela Schoeb 1, Elizabeth M Winter 1, Maria A Sleddering 1, Mirjam A Lips 1, Abbey Schepers 2, Marieke Snel 1, Natasha M Appelman-Dijkstra 1 J Clin Endocrinol Metab. 2021 Jun 16;106(7):e2527-e2534. doi: 10.1210/clinem/dgab207. PMID: 33780545 PMCID: PMC8266436 DOI: 10.1210/clinem/dgab207 Context: In primary hyperparathyroidism (PHPT) bone mineral density (BMD) is typically decreased in cortical bone and relatively preserved in trabecular bone. An increased fracture rate is observed however not only at peripheral sites …

Bone Material Strength Index as Measured by Impact Microindentation is Low in Patients with Primary Hyperparathyroidism Read More »

Anna G Nilsson 1, Daniel Sundh 1, Lisa Johansson 1, Martin Nilsson 1, Dan Mellström 1, Robert Rudäng 1, Michail Zoulakis 1, Märit Wallander 1 2, Anna Darelid 1, Mattias Lorentzon 1 J Bone Miner Res. 2017 May;32(5):1062-1071. doi: 10.1002/jbmr.3057. Epub 2017 Jan 18. PMID: 27943408 DOI: 10.1002/jbmr.3057 Type 2 diabetes mellitus (T2DM) is associated with an increased risk of fractures according to several studies. The underlying mechanisms remain unclear, although small case-control studies indicate poor quality of the cortical …

Type 2 Diabetes Mellitus Is Associated With Better Bone Microarchitecture But Lower Bone Material Strength and Poorer Physical Function in Elderly Women: A Population-Based Study Read More »