Secondary Osteoporosis, Diseases & Underlying Conditions

Eva M Wölfel 1, Imke A K Fiedler 2, Sofie Dragoun Kolibova 1, Johannes Krug 1, Mei-Chun Lin 1, Bashar Yazigi 1, Anna K Siebels 1, Herbert Mushumba 3, Birgit Wulff 3, Benjamin Ondruschka 3, Klaus Püschel 3, Claus C Glüer 4, Katharina Jähn-Rickert 5, Björn Busse 6PMID: 36113843DOI: 10.1016/j.bone.2022.116546 Diabetes mellitus is a metabolic disease affecting bone tissue at different length-scales. Higher fracture risk in diabetic patients is difficult to detect with common clinical fracture risk assessment due to normal or high …

Human tibial cortical bone with high porosity in type 2 diabetes mellitus is accompanied by distinctive bone material properties Read More »

Diana Ovejero 1, Natalia Garcia-Giralt 2, Núria Martínez-Gil 3, Raquel Rabionet 3, Susanna Balcells 3, Daniel Grinberg 3, Luis Alberto Pérez-Jurado 4, Xavier Nogués 2, Iñigo Etxebarria-Forondad 5PMID: 35623613DOI: 10.1016/j.bone.2022.116450 High bone mass (HBM) disorders are a clinically and genetically heterogeneous subgroup of rare skeletal dysplasias. Here we present a case of a previously unreported familial skeletal dysplasia characterized by HBM and lucent bone lesions that we aimed to clinically characterize and genetically …

Clinical description and genetic analysis of a novel familial skeletal dysplasia characterized by high bone mass and lucent bone lesions Read More »

Nicola Hepp 1, Lars Folkestad 2, Simone Møllebæk 3, Anja Lisbeth Frederiksen 4, Morten Duno 5, Niklas Rye Jørgensen 6, Anne Pernille Hermann 3, Jens-Erik Beck Jensen 7PMID: 35421614DOI: 10.1016/j.bone.2022.116420 Background: Hypophosphatasia (HPP) is an autosomal recessive or dominate disease affecting bone mineralization, and adults with HPP are in risk to develop metatarsal stress fractures and femoral pseudofractures. Given to the scarce data on the bone quality and its association to the …

Bone-microarchitecture and bone-strength in a sample of adults with hypophosphatasia and a matched reference population assessed by HR-pQCT and impact microindentation Read More »

Sundeep Khosla 1, Parinya Samakkarnthai 2 3, David G Monroe 2, Joshua N Farr 2PMID: 34518671PMCID: PMC8605611DOI: 10.1038/s41574-021-00555-5  Fracture risk is increased in patients with type 2 diabetes mellitus (T2DM). In addition, these patients sustain fractures despite having higher levels of areal bone mineral density, as measured by dual-energy X-ray absorptiometry, than individuals without T2DM. Thus, additional factors such as alterations in bone quality …

Update on the pathogenesis and treatment of skeletal fragility in type 2 diabetes mellitus Read More »

Kara L Holloway-Kew 1, Amelia Betson 2, Pamela G Rufus-Membere 2, James Gaston 2, Adolfo Diez-Perez 3, Mark A Kotowicz 4, Julie A Pasco 5PMID: 33049369DOI: 10.1016/j.bone.2020.115685 Background: Individuals with type 2 diabetes (T2DM) are at increased fracture risk, with bone mineral density (BMD) measurements underestimating risk. Impact microindentation (IMI), a technique that measures bone microindentation distances, expressed as bone material strength index (BMSi), may improve fracture risk estimation in …

Impact microindentation in men with impaired fasting glucose and type 2 diabetes Read More »

Unni Syversen 1 2, Mats Peder Mosti 1 3, Ida Maria Mynarek 1, Trude Seselie Jahr Vedal 1, Kristin Aasarød 1 4, Trude Basso 5, Janne E Reseland 6, Per Medbøe Thorsby 7, Bjorn O Asvold 2 8, Erik Fink Eriksen 6, Astrid Kamilla Stunes 1 3PMID: 34289447PMCID: PMC8428087DOI: 10.1530/EC-21-0193 Objective: Type 1 diabetes (T1D) is associated with substantial fracture risk. Bone mineral density (BMD) is, however, only modestly reduced, suggesting impaired bone microarchitecture and/or bone material properties. Yet, the skeletal abnormalities …

Evidence of impaired bone quality in men with type 1 diabetes: a cross-sectional study Read More »

Kara L Holloway-Kew 1, Amelia Betson 2, Pamela G Rufus-Membere 2, James Gaston 2, Adolfo Diez-Perez 3, Mark A Kotowicz 4, Julie A Pasco 5 Bone. 2021 Jan;142:115685. doi: 10.1016/j.bone.2020.115685. Epub 2020 Oct 10. PMID: 33049369 DOI: 10.1016/j.bone.2020.115685 Background: Individuals with type 2 diabetes (T2DM) are at increased fracture risk, with bone mineral density (BMD) measurements underestimating risk. Impact microindentation (IMI), a technique that measures bone microindentation distances, expressed …

Impact microindentation in men with impaired fasting glucose and type 2 diabetes Read More »

F Malgo 1, N A T Hamdy 1, T J Rabelink 2, H M Kroon 3, K M J A Claessen 4, A M Pereira 4, N R Biermasz 4, N M Appelman-Dijkstra 1 Eur J Endocrinol. 2017 Mar;176(3):339-347. doi: 10.1530/EJE-16-0808. Epub 2017 Jan 11. PMID: 28077497 DOI: 10.1530/EJE-16-0808 Objective: Acromegaly is a rare disease caused by excess growth hormone (GH) production by the pituitary adenoma. The skeletal complications of GH and IGF-1 excess include …

Bone material strength index as measured by impact microindentation is altered in patients with acromegaly Read More »

Kara L Holloway-Kew 1, Pamela Rufus-Membere 2, Kara B Anderson 2, Amelia Betson 2, James Gaston 2, Mark A Kotowicz 3, Adolfo Diez-Perez 4, Natalie K Hyde 2, Julie A Pasco 5 Bone. 2020 Apr;133:115241. doi: 10.1016/j.bone.2020.115241. Epub 2020 Jan 16. PMID: 31954850 DOI: 10.1016/j.bone.2020.115241 Background: Patients with chronic kidney disease (CKD) are at high risk for fracture. The ability of bone mineral density (BMD) to predict fractures in CKD patients has been inconsistent. Other measures such …

Bone material strength index is associated with prior fracture in men with and without moderate chronic kidney disease Read More »

Guillermina Orduna 1, Leonardo Mellibovsky 1, Eugenia Abella 2, Xavier Nogués 3, Roser Granero 4, Natalia García-Giralt 1, Marta Pineda-Moncusí 1, Roberto Güerri-Fernández 1, Daniel Prieto-Alhambra 5, Adolfo Díez-Pérez 1 J Bone Miner Metab. 2020 Jul;38(4):563-569. doi: 10.1007/s00774-020-01084-3. Epub 2020 Jan 23. PMID: 31974675 DOI: 10.1007/s00774-020-01084-3 Introduction: Monoclonal gammopathy of uncertain significance (MGUS) is highly prevalent in older adults and affects bone structure, with osteoporosis and increased risk of fractures in up to 14% of affected patients. Dual-energy X-ray …

Bone tissue quality in patients with monoclonal gammopathy of uncertain significance Read More »