Osteoporosis & Fracture

Pamela Rufus-Membere 1 2, Kara L Holloway-Kew 3, Adolfo Diez-Perez 4, Natasha M Appelman-Dijkstra 5, Mary L Bouxsein 6, Erik F Eriksen 7, Joshua N Farr 8, Sundeep Khosla 8, Mark A Kotowicz 3 9 10, Xavier Nogues 11, Mishaela Rubin 12, Julie A Pasco 3 9 10 13PMID: 36729139PMCID: PMC9968254 DOI: 10.1007/s00223-022-01047-y Impact microindentation (IMI) is a novel technique for assessing bone material strength index (BMSi) in vivo, by measuring the depth of a micron-sized, spherical tip into cortical bone that is then indexed …

Reference Intervals for Bone Impact Microindentation in Healthy Adults: A Multi-Centre International Study Read More »

M Schoeb 1, E M Winter 1, F Malgo 1, I B Schipper 2, R J P van der Wal 3, S E Papapoulos 1, N M Appelman-Dijkstra 4PMID: 35307747PMCID: PMC9187533DOI: 10.1007/s00198-022-06368-0 Bone material properties were assessed using impact microindentation in patients with high-energy trauma fractures. Compared to patients with low-energy trauma fractures, bone material strength index was significantly higher in patients with high-energy trauma fractures, and did not …

Bone material strength index as measured by in vivo impact microindentation is normal in subjects with high-energy trauma fractures Read More »

Rufus-Membere P, Anderson KA, Holloway-Kew KL, Kotowicz MA, Diez-Perez A, Pasco JA Preprint from Research Square, 18 Oct 2022DOI: 10.21203/rs.3.rs-2114758/v1 PPR: PPR559565  Impact microindentation (IMI) measures bone material strength index (BMSi) in vivo. However, its ability to predict fractures is still uncertain. This study aimed to determine the association between BMSi and 10-year fracture probability, as calculated by the …

Associations between bone material strength index and FRAX scores Read More »

Xavier Nogués 1, Daniel Prieto-Alhambra 2, Roberto Güerri-Fernández 1, Natalia Garcia-Giralt 3, Jaime Rodriguez-Morera 1, Lourdes Cos 1, Leonardo Mellibovsky 1, Adolfo Díez Pérez 4 Bone. 2017 Oct;103:64-69. doi: 10.1016/j.bone.2017.06.018. Epub 2017 Jun 24. PMID: 28655603 DOI: 10.1016/j.bone.2017.06.018 Background: Some patients experience fractures while receiving oral bisphosphonates (BPs) treatment. Clinical risk factors, advanced bone density loss, and microarchitecture deterioration have been associated with such fractures but bone tissue properties other than bone mineral density (BMD) …

Fracture during oral bisphosphonate therapy is associated with deteriorated bone material strength index Read More »

Daysi Duarte Sosa 1, Erik Fink Eriksen 2 Calcif Tissue Int. 2017 Jul;101(1):34-42. doi: 10.1007/s00223-017-0256-5. Epub 2017 Feb 28. PMID: 28246929 DOI: 10.1007/s00223-017-0256-5 The aim of the study was to test, whether bone material strength differs between different subtypes of osteoporotic fracture and assess whether it relates to vertebral fracture severity. Cortical bone material strength index (BMSi) was measured by impact microindentation in …

Reduced Bone Material Strength is Associated with Increased Risk and Severity of Osteoporotic Fractures. An Impact Microindentation Study Read More »

Tamara D Rozental 1 2, Kempland C Walley 1, Serkalem Demissie 3, Signe Caksa 4, Adriana Martinez-Betancourt 4, Amber M Parker 1, Joy N Tsai 4 5, Elaine W Yu 4 5, Mary L Bouxsein 1 2 4 J Bone Miner Res. 2018 Apr;33(4):621-626. doi: 10.1002/jbmr.3338. Epub 2017 Dec 5. PMID: 29115684 DOI: 10.1002/jbmr.3338 We tested whether cortical bone tissue properties assessed by in vivo impact microindentation would distinguish postmenopausal women with recent distal radius (DRF) or hip fracture (HF) from nonfracture …

Bone Material Strength Index as Measured by Impact Microindentation in Postmenopausal Women With Distal Radius and Hip Fractures Read More »

Lisa Johansson 1 2, Daniel Sundh 1, Michael Zoulakis 1, Robert Rudäng 1, Anna Darelid 1, Helena Brisby 2 3, Anna G Nilsson 1, Dan Mellström 1 4, Mattias Lorentzon 1 4 J Bone Miner Res. 2018 Feb;33(2):250-260. doi: 10.1002/jbmr.3297. Epub 2017 Nov 15. PMID: 28926125 DOI: 10.1002/jbmr.3297 Vertebral fractures (VFs) are among the most severe and prevalent osteoporotic fractures. Their association with bone microstructure have been investigated in several retrospective case-control studies with spine radiography for diagnosis of VF. The …

The Prevalence of Vertebral Fractures Is Associated With Reduced Hip Bone Density and Inferior Peripheral Appendicular Volumetric Bone Density and Structure in Older Women Read More »

Kristin L Popp 1, Signe Caksa 2, Adriana Martinez-Betancourt 2, Amy Yuan 2, Joy Tsai 1, Elaine W Yu 1, Mary L Bouxsein 1 3 J Bone Miner Res. 2019 Jan;34(1):75-82. doi: 10.1002/jbmr.3590. Epub 2018 Nov 5. PMID: 30281863 DOI: 10.1002/jbmr.3590 Atypical femoral fractures are rare fractures that occur in the subtrochanteric or diaphyseal region of the femur with minimal or no trauma. Though the association of atypical femoral fractures (AFFs) and bisphosphonate (BP) …

Cortical Bone Material Strength Index and Bone Microarchitecture in Postmenopausal Women With Atypical Femoral Fractures Read More »

Pamela Rufus-Membere 1, Kara L Holloway-Kew 1, Adolfo Diez-Perez 2, Mark A Kotowicz 1 3 4, Julie A Pasco 1 3 4 Endocrinology. 2019 Sep 1;160(9):2143-2150. doi: 10.1210/en.2019-00415. PMID: 31310275 DOI: 10.1210/en.2019-00415 Impact microindentation (IMI) measures bone material strength index (BMSi) in vivo. However, clinical risk factors that affect BMSi are largely unknown. This study investigated associations between BMSi and clinical risk factors for fracture in men. BMSi was measured using the …

Associations Between Bone Impact Microindentation and Clinical Risk Factors for Fracture Read More »

Frank Malgo 1, Neveen A T Hamdy, Socrates E Papapoulos, Natasha M Appelman-Dijkstra J Clin Endocrinol Metab. 2015 May;100(5):2039-45. doi: 10.1210/jc.2014-4346. Epub 2015 Mar 13. PMID: 25768670 DOI: 10.1210/jc.2014-4346 Context: Bone mineral density (BMD) does not fully capture fracture risk as the majority of fractures occur in patients with osteopenia, suggesting that altered bone material properties and changes in microarchitecture may contribute to fracture …

Bone material strength as measured by microindentation in vivo is decreased in patients with fragility fractures independently of bone mineral density Read More »